Historically, the American and Cuban governments haven't done so well together, but the people are a far different story. In general, the Cuban people respect and have a genuine liking for Americans. You'll fit in quite well here! The USA is an indelible part of Cuban history and there are many positive reminders of such (just check out the cars). Many Nationals have American blood due to pre 1959 relations and our current base at Gitmo.
In addition, safety has never been an issue with any Experience Cuba Now passenger. Since our first trip in 2002, we've never had any problems. Our passengers, both men and women, describe this island as one of the safest places they have ever been including their own home town. That being said, plain old common sense wherever we travel should always be applied!